Ziocin-500
Form: Tablet
Strength: 500mg
Generic Name: Azithromycin
Company: APC Pharma Limited
MRP:৳ 30.0 (Tablet)
Is Antibiotic: Yes
Indications
Ziocin-500 is used to treat bacterial eye infections caused by certain bacteria like CDC coryneform group G, Haemophilus influenzae, Staphylococcus aureus, Streptococcus mitis group, and Streptococcus pneumonia.
Pharmacology
Ziocin-500 is stable in acid and can be taken orally without needing protection from stomach acid. Ziocin-500 is absorbed easily, especially when taken on an empty stomach. After taking Ziocin-500, the highest level in the body is reached in 2.1 to 3.2 hours. Ziocin-500 is concentrated in the white blood cells and is delivered to the infection site. The drug is stored in the tissues and released over time, with levels in tissues being over 50 times higher than in the blood. This allows a single dose to remain effective for several days. After one dose, Ziocin-500 stays in the body for up to 68 hours. Ziocin-500 is mainly eliminated through bile, with a small amount leaving the body unchanged in urine.
Microbiology
Ziocin-500 works by binding to a part of bacteria, stopping them from making proteins, which prevents the bacteria from growing. Ziocin-500 does not affect the bacteria’s genetic material. Ziocin-500 is effective against many bacteria, including:
- Gram-positive bacteria like Staphylococcus aureus, Streptococcus pneumoniae, and Streptococcus pyogenes.
- Gram-negative bacteria like Haemophilus influenzae, Neisseria gonorrhoeae, and Moraxella catarrhalis.
- Other bacteria like Chlamydia pneumoniae, Mycoplasma pneumoniae, and Chlamydia trachomatis.
Ziocin-500 works even against some bacteria that produce betalactamase, an enzyme that makes other antibiotics less effective.
Dosage & Administration
Adults and children 1 year and older: Put 1 drop in the affected eye(s) twice a day for the first 2 days, then once a day for the next 5 days.
Pediatric use: Ziocin-500 has not been tested in children under 1 year of age, so Ziocin-500 is not recommended for them.
Interaction
No interaction studies have been done with Azithromycin Eye Drops.
Contraindications
Ziocin-500 should not be used by anyone who is allergic to any of its ingredients.
Side Effects
Possible side effects include eye irritation, skin irritation, corneal damage, dry eyes, and inflammation of the cornea.
Pregnancy & Lactation
Ziocin-500 is classified as Pregnancy Category B, meaning no harm was found in animal studies. However, Ziocin-500 should only be used during pregnancy if absolutely necessary. Ziocin-500 is not known if Ziocin-500 passes into breast milk, so caution is advised when using Ziocin-500 while nursing.
Precautions & Warnings
Ziocin-500 is only for use in the eyes. Ziocin-500 should not be used in the bloodstream, injected into the eye, or placed into the inner part of the eye.
Overdose Effects
No specific overdose effects have been reported.
Therapeutic Class
Ziocin-500 belongs to the Macrolide class of antibiotics.
Storage Conditions
Store the unopened bottle in the fridge between 2°C to 8°C. After opening, keep Ziocin-500 at room temperature (25°C) for up to 14 days. Discard Ziocin-500 after 14 days.
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