Zithrin
Form: IV Infusion
Strength: 500mg/vial
Generic Name: Azithromycin
Company: Renata Limited
MRP:৳ 460.0 (IV Infusion)
Is Antibiotic: Yes
Indications
Zithrin is used to treat bacterial eye infections caused by certain bacteria like CDC coryneform group G, Haemophilus influenzae, Staphylococcus aureus, Streptococcus mitis group, and Streptococcus pneumonia.
Pharmacology
Zithrin is stable in acid and can be taken orally without needing protection from stomach acid. Zithrin is absorbed easily, especially when taken on an empty stomach. After taking Zithrin, the highest level in the body is reached in 2.1 to 3.2 hours. Zithrin is concentrated in the white blood cells and is delivered to the infection site. The drug is stored in the tissues and released over time, with levels in tissues being over 50 times higher than in the blood. This allows a single dose to remain effective for several days. After one dose, Zithrin stays in the body for up to 68 hours. Zithrin is mainly eliminated through bile, with a small amount leaving the body unchanged in urine.
Microbiology
Zithrin works by binding to a part of bacteria, stopping them from making proteins, which prevents the bacteria from growing. Zithrin does not affect the bacteria’s genetic material. Zithrin is effective against many bacteria, including:
- Gram-positive bacteria like Staphylococcus aureus, Streptococcus pneumoniae, and Streptococcus pyogenes.
- Gram-negative bacteria like Haemophilus influenzae, Neisseria gonorrhoeae, and Moraxella catarrhalis.
- Other bacteria like Chlamydia pneumoniae, Mycoplasma pneumoniae, and Chlamydia trachomatis.
Zithrin works even against some bacteria that produce betalactamase, an enzyme that makes other antibiotics less effective.
Dosage & Administration
Adults and children 1 year and older: Put 1 drop in the affected eye(s) twice a day for the first 2 days, then once a day for the next 5 days.
Pediatric use: Zithrin has not been tested in children under 1 year of age, so Zithrin is not recommended for them.
Interaction
No interaction studies have been done with Azithromycin Eye Drops.
Contraindications
Zithrin should not be used by anyone who is allergic to any of its ingredients.
Side Effects
Possible side effects include eye irritation, skin irritation, corneal damage, dry eyes, and inflammation of the cornea.
Pregnancy & Lactation
Zithrin is classified as Pregnancy Category B, meaning no harm was found in animal studies. However, Zithrin should only be used during pregnancy if absolutely necessary. Zithrin is not known if Zithrin passes into breast milk, so caution is advised when using Zithrin while nursing.
Precautions & Warnings
Zithrin is only for use in the eyes. Zithrin should not be used in the bloodstream, injected into the eye, or placed into the inner part of the eye.
Overdose Effects
No specific overdose effects have been reported.
Therapeutic Class
Zithrin belongs to the Macrolide class of antibiotics.
Storage Conditions
Store the unopened bottle in the fridge between 2°C to 8°C. After opening, keep Zithrin at room temperature (25°C) for up to 14 days. Discard Zithrin after 14 days.
Similar Brands of Azithromycin (IV Infusion – 500mg/vial)
| Brand Name | Form | Strength | Company | MRP (৳) |
|---|---|---|---|---|
| Avalon | IV Infusion | 500mg/vial | EDCL | 0.0 |
| Azithrocin IV 500 | IV Infusion | 500mg/vial | Beximco Pharmaceuticals Ltd. | 460.0 |
| Rozith IV | IV Infusion | 500mg/vial | Healthcare Pharmaceuticals Ltd. | 460.0 |
| Simpli 3 | IV Infusion | 500mg/vial | Beacon Pharmaceuticals Ltd. | 461.38 |
| Zibac | IV Infusion | 500mg/vial | Popular Pharmaceuticals Ltd. | 461.74 |
| Zimax IV | IV Infusion | 500mg/vial | Square Pharmaceuticals Ltd. | 461.38 |