Zithrox
Form: Powder for Suspension
Strength: 200mg/5ml
Generic Name: Azithromycin
Company: Eskayef Pharmaceuticals Ltd.
MRP:৳ 100.0 (20ml bot)
Is Antibiotic: Yes
Indications
Zithrox is used to treat bacterial eye infections caused by certain bacteria like CDC coryneform group G, Haemophilus influenzae, Staphylococcus aureus, Streptococcus mitis group, and Streptococcus pneumonia.
Pharmacology
Zithrox is stable in acid and can be taken orally without needing protection from stomach acid. Zithrox is absorbed easily, especially when taken on an empty stomach. After taking Zithrox, the highest level in the body is reached in 2.1 to 3.2 hours. Zithrox is concentrated in the white blood cells and is delivered to the infection site. The drug is stored in the tissues and released over time, with levels in tissues being over 50 times higher than in the blood. This allows a single dose to remain effective for several days. After one dose, Zithrox stays in the body for up to 68 hours. Zithrox is mainly eliminated through bile, with a small amount leaving the body unchanged in urine.
Microbiology
Zithrox works by binding to a part of bacteria, stopping them from making proteins, which prevents the bacteria from growing. Zithrox does not affect the bacteria’s genetic material. Zithrox is effective against many bacteria, including:
- Gram-positive bacteria like Staphylococcus aureus, Streptococcus pneumoniae, and Streptococcus pyogenes.
- Gram-negative bacteria like Haemophilus influenzae, Neisseria gonorrhoeae, and Moraxella catarrhalis.
- Other bacteria like Chlamydia pneumoniae, Mycoplasma pneumoniae, and Chlamydia trachomatis.
Zithrox works even against some bacteria that produce betalactamase, an enzyme that makes other antibiotics less effective.
Dosage & Administration
Adults and children 1 year and older: Put 1 drop in the affected eye(s) twice a day for the first 2 days, then once a day for the next 5 days.
Pediatric use: Zithrox has not been tested in children under 1 year of age, so Zithrox is not recommended for them.
Interaction
No interaction studies have been done with Azithromycin Eye Drops.
Contraindications
Zithrox should not be used by anyone who is allergic to any of its ingredients.
Side Effects
Possible side effects include eye irritation, skin irritation, corneal damage, dry eyes, and inflammation of the cornea.
Pregnancy & Lactation
Zithrox is classified as Pregnancy Category B, meaning no harm was found in animal studies. However, Zithrox should only be used during pregnancy if absolutely necessary. Zithrox is not known if Zithrox passes into breast milk, so caution is advised when using Zithrox while nursing.
Precautions & Warnings
Zithrox is only for use in the eyes. Zithrox should not be used in the bloodstream, injected into the eye, or placed into the inner part of the eye.
Overdose Effects
No specific overdose effects have been reported.
Therapeutic Class
Zithrox belongs to the Macrolide class of antibiotics.
Storage Conditions
Store the unopened bottle in the fridge between 2°C to 8°C. After opening, keep Zithrox at room temperature (25°C) for up to 14 days. Discard Zithrox after 14 days.
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|---|---|---|---|---|
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