Zithrox 250
Form: Tablet
Strength: 250mg
Generic Name: Azithromycin
Company: Eskayef Pharmaceuticals Ltd.
MRP:৳ 25.0 (Strip=6)
Per Piece: ৳ 4.17
Is Antibiotic: Yes
Indications
Zithrox 250 is used to treat bacterial eye infections caused by certain bacteria like CDC coryneform group G, Haemophilus influenzae, Staphylococcus aureus, Streptococcus mitis group, and Streptococcus pneumonia.
Pharmacology
Zithrox 250 is stable in acid and can be taken orally without needing protection from stomach acid. Zithrox 250 is absorbed easily, especially when taken on an empty stomach. After taking Zithrox 250, the highest level in the body is reached in 2.1 to 3.2 hours. Zithrox 250 is concentrated in the white blood cells and is delivered to the infection site. The drug is stored in the tissues and released over time, with levels in tissues being over 50 times higher than in the blood. This allows a single dose to remain effective for several days. After one dose, Zithrox 250 stays in the body for up to 68 hours. Zithrox 250 is mainly eliminated through bile, with a small amount leaving the body unchanged in urine.
Microbiology
Zithrox 250 works by binding to a part of bacteria, stopping them from making proteins, which prevents the bacteria from growing. Zithrox 250 does not affect the bacteria’s genetic material. Zithrox 250 is effective against many bacteria, including:
- Gram-positive bacteria like Staphylococcus aureus, Streptococcus pneumoniae, and Streptococcus pyogenes.
- Gram-negative bacteria like Haemophilus influenzae, Neisseria gonorrhoeae, and Moraxella catarrhalis.
- Other bacteria like Chlamydia pneumoniae, Mycoplasma pneumoniae, and Chlamydia trachomatis.
Zithrox 250 works even against some bacteria that produce betalactamase, an enzyme that makes other antibiotics less effective.
Dosage & Administration
Adults and children 1 year and older: Put 1 drop in the affected eye(s) twice a day for the first 2 days, then once a day for the next 5 days.
Pediatric use: Zithrox 250 has not been tested in children under 1 year of age, so Zithrox 250 is not recommended for them.
Interaction
No interaction studies have been done with Azithromycin Eye Drops.
Contraindications
Zithrox 250 should not be used by anyone who is allergic to any of its ingredients.
Side Effects
Possible side effects include eye irritation, skin irritation, corneal damage, dry eyes, and inflammation of the cornea.
Pregnancy & Lactation
Zithrox 250 is classified as Pregnancy Category B, meaning no harm was found in animal studies. However, Zithrox 250 should only be used during pregnancy if absolutely necessary. Zithrox 250 is not known if Zithrox 250 passes into breast milk, so caution is advised when using Zithrox 250 while nursing.
Precautions & Warnings
Zithrox 250 is only for use in the eyes. Zithrox 250 should not be used in the bloodstream, injected into the eye, or placed into the inner part of the eye.
Overdose Effects
No specific overdose effects have been reported.
Therapeutic Class
Zithrox 250 belongs to the Macrolide class of antibiotics.
Storage Conditions
Store the unopened bottle in the fridge between 2°C to 8°C. After opening, keep Zithrox 250 at room temperature (25°C) for up to 14 days. Discard Zithrox 250 after 14 days.
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