Zoxanid
Form: Tablet
Strength: 500mg
Generic Name: Nitazoxanide
Company: Silva Pharmaceuticals Ltd.
MRP:৳ 10.0 (Tablet)
Is Antibiotic: No
Indications
Zoxanid is used to treat diarrhea caused by Cryptosporidium parvum, Giardia lamblia, and Entamoeba histolytica.
Pharmacology
Zoxanid is a synthetic drug taken by mouth to fight protozoal infections. Zoxanid works by blocking an important enzyme called Pyruvate Ferredoxin Oxido Reductase (PFOR), which is needed for the energy production of the protozoa. This stops the growth of the protozoa that cause infections like Cryptosporidium parvum and Giardia lamblia.
Dosage & Administration
Age 1-3 years: 1 teaspoon (5 ml) of suspension every 12 hours for 3 days.
Age 4-11 years: 2 teaspoons (10 ml) of suspension every 12 hours for 3 days.
Age 12 years or older: 5 teaspoons (25 ml) of suspension or 1 tablet every 12 hours for 3 days.
Zoxanid is recommended to take this with food.
Interaction
Zoxanid is highly attached to plasma proteins. Therefore, caution should be taken when using Zoxanid with other drugs that also bind strongly to plasma proteins, especially those with a narrow therapeutic range.
Contraindications
Zoxanid is not recommended for patients who are allergic to Nitazoxanide or any of its ingredients.
Side Effects
Common side effects include mild stomach pain, vomiting, and headache. Rare side effects may include nausea, loss of appetite, gas, increased hunger, enlarged salivary glands, higher creatinine or liver enzyme levels, itchy skin, stuffy nose, sweating, dizziness, and discolored urine.
Pregnancy & Lactation
Zoxanid is categorized as pregnancy category B by the FDA. However, there are no well-controlled studies in pregnant women. Animal studies do not always predict how Zoxanid will affect humans, so Zoxanid should only be used during pregnancy if necessary. Nitazoxanide can pass into breast milk, so caution should be taken when using Zoxanid while breastfeeding.
Precautions & Warnings
Zoxanid should be used with caution in patients with liver or kidney disease.
Overdose Effects
N/A
Therapeutic Class
Anti-diarrheal Antiprotozoal
Storage Conditions
Keep in a dry place, away from light and heat. Keep out of the reach of children.
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